In the aftermath of the car crash, the surviving Winchesters go to the hospital, where one is stalked by a Reaper while another must consider sacrificing himself to save the others.
After the events at the hospital, the brothers have no idea where the demon that killed their mother is hiding. While biding their time trying to come up with an idea, they investigate murders committed by a killer clown.
Sam and Dean encounter a vampire hunter whose obsession may get them all killed.
Dean and Sam investigate the death of a young college student who died in a car accident, but whose grave is now surrounded by a circle of dead plants.
Sam and Dean meet Andy Gallagher, a slacker with psychic powers of persuasion. Once the brothers learn that Andy’s family was visited by the Demon, Sam wonders if he could be one of the special children.
Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.
Sam and Dean investigate the murder of a lawyer and his wife, who claimed to have seen a ghost before they were killed. However, local authorities arrest the Winchesters after looking into their past.
Dean calls a demon to make a deal to save a man named Evan Hudson, in exchange for himself. While making the deal, the demon confronts Dean’s worst nightmare about their dad.
Sam has a vision of Dean shooting a defenseless man, and they go to the town of River Grove, where they find the townspeople have been possessed by a virus that makes them violent.
Sam meets a woman who shares his ability to have visions, and she warns him that she has seen the future... where he dies in an explosion.
Sam and Dean investigate an Connecticut inn run by a single mother where mysterious deaths are taking place. They find evidence of Hoodoo, and try to figure out who is causing the chaos.
The Winchesters investigate a series of crimes where robbers with no criminal past commit suicide after the hold-ups.
An angel causes people to cheerfully go out to murder, and when the Winchesters investigate one of them falls under its sway.
Sam contacts Dean after being missing for a week. When they reunite, Dean finds Sam covered in blood and with no recollection of what happened.
The Winchester brothers seek the help of their family friend Bobby while investigating a series of unexplained happenings on a local college campus.
A fatal automobile accident from 1992 leaves an angry apparition haunting a remote stretch of highway, and Sam and Dean try to lay it to rest.
Sam and Dean investigate a brutal death and discover that the killer is a lycanthrope: a werewolf.
Sam and Dean discover that a group of ghosts are attempting to shut down production of a movie that they feel is mocking them.
Sam and Dean allow themselves to be arrested in order to investigate a series of murders inside a penitentiary. However things get complicated when FBI agent Henricksen shows up to take over their case.
Dean is attacked by a Djinn... and finds himself in a new reality where his mother is still alive and a mysterious woman holds the key to everything.
Sam and other "special children" are abducted by the Yellow-Eyed Demon and taken to a ghost town, where the ultimate battle must start.
After the fight between Jake and Sam, Dean has to make the ultimate sacrifice for his brother. Meanwhile the Yellow-Eyed Demon has his new servant and plans to unleash the hordes of Hell.